Unexpected similarity of intestinal sugar absorption by SGLT1 and apical GLUT2 in an insect (Aphidius ervi, Hymenoptera) and mammals.

The unexpected similarity of intestinal sugar absorption by SGLT1 and apical GLUT2 in an insect (Aphidius ervi, Hymenoptera) and mammals

Apical GLUT2: a major pathway of intestinal sugar absorption.

Understanding the mechanisms that determine postprandial fluctuations in blood glucose concentration is central for effective glycemic control in the management of diabetes. Intestinal sugar absorption is one such mechanism, and studies on its increase in experimental diabetes led us to propose a new model of sugar absorption. In the apical GLUT2 model, the glucose transported by the Na(+)/gluc...

Stress and intestinal sugar absorption.

TWENTY YEARS AGO, Ugolev et al. (15) noted that “under physiological conditions [the] two systems of glucose transport, Na -dependent and Na -independent, function. The first one is less potent but more resistant to experimental influences.” This statement sums up fairly accurately what has happened in the field of intestinal sugar absorption in the last six years as exemplified by increases in...

Response to Comment on: Gorboulev et al. Na+-d-glucose Cotransporter SGLT1 Is Pivotal for Intestinal Glucose Absorption and Glucose-Dependent Incretin Secretion. Diabetes 2012;61:187–196

The elegant paper from Koepsell and colleagues (1) demonstrates the apical GLUT2 mechanism, but appears at first sight to question its significance. However, when set in a physiological context, the results are those expected from the three roles of SGLT1 and the differences between fed rat and starved mouse. SGLT1 acts as 1) a transporter and 2) a powerful scavenger. In 2000, my laboratory pro...

The small intestinal epithelia of beef steers differentially express sugar transporter messenger ribonucleic acid in response to abomasal versus ruminal infusion of starch hydrolysate.

In mammals, the absorption of monosaccharides from small intestinal lumen involves at least 3 sugar transporters (SugT): sodium-dependent glucose transporter 1 (SGLT1; gene SLC5A1) transports glucose and galactose, whereas glucose transporter (GLUT) 5 (GLUT5; gene SLC2A5) transports fructose, across the apical membrane of enterocytes. In contrast, GLUT2 (gene SLC2A2) transports all of these sug...